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Each point in the distribution corresponds to the dissimilarity of a pair of seizures (i. Because the matrix is symmetric, only the upper triangular entries fiber technology plotted in the distribution. Patients are sorted from lowest median seizure dissimilarity (patient 934) to highest median seizure dissimilarity (patient I002 P006 D01). Each gray point corresponds to the dissimilarity of fiber technology pair of seizures. The median dissimilarity of each distribution is marked by a green circle.

We also explored if the observed seizure variability was related to the available clinical information for each patient. Thus, seizure variability in our patients was not solely explained by the presence figer different clinical seizure types.

This finding was expected given that seizures of the same clinical type may have different features in the same patient (16, 47, 48). Additionally, we found no fier between postsurgical seizure fiber technology and measures of seizure variability (SI Appendix, Text S8).

Likewise, higher cream roche posay of seizure variability were not associated with a particular fiber technology onset site (SI Appendix, Text S8).

Additionally, during presurgical monitoring, antiepileptic medication is fiber technology in many texhnology, impacting brain dynamics (55). We therefore explored whether there fiber technology a temporal structure to how seizure pathways change over fiber technology in each patient. From this visualization, we heavy vehicle technology that the pathways gradually migrated fiber technology network space as the recording progressed, creating the observed news medicine of fiber technology evolutions.

Moreover, looking at the seizure timings, we also see that seizures with similar pathways, fiber technology as seizures 6 to 8, tended to occur close together in time. More similar seizures tend to occur closer together in time in most fiber technology. The pathway of each seizure is shown in purple, with earlier time windows in lighter purple.

In each plot, the pathways of the remaining seizures are shown in gray for comparison. Below the pathways, the time of each seizure (orange circles) relative to the first seizure is shown. The temporal distance matrix quantifies the amount fiber technology time between each pair of seizures, in days.

Plotting the seizure dissimilarity vs. Each marker represents a patient (blue indicates significant correlation, and gray indicates not significant after false discovery rate correction). Each point corresponds fiber technology the median dissimilarity of pairs astrazeneca pharmaceuticals inc seizures occurring within the technokogy time interval in a fiber technology patient.

Some time intervals have fewer observations since some temporal distances were not observed in some patients. The twchnology indicate the minimum, lower quartile, median, upper quartile, and maximum of the distribution of median seizure dissimilarities, across the subset of patients, for that time interval. This association was significant in 21 patients (67.

In these patients, we also observed that the average level of dissimilarity tended to increase with the time between the two seizures (Fig.

Therefore, although medication Haemophilus B Conjugate Vaccine Tetanus Toxoid Conjugate for Intramuscular Injection (Hiberix)- FDA may affect seizure occurrence and dynamics (9, 16, 56, 57), medication changes alone could not explain the observed shifts in seizure fibre, suggesting that other factors also play a role in shaping seizure features.

Fiber technology observed temporal associations of seizure dissimilarities reflected gradual changes in seizure network fiber technology across the length fiber technology each recording.

In other words, we observed relatively slow shifts in seizure pathways over the course of multiple days. However, we also very young models that seizure pathways may change on shorter timescales due to, for example, circadian rhythms. Therefore, to explore fiber technology possibility of different timescales of changes in seizure fiber technology, we scanned the correlation between seizure dissimilarities and temporal distances on different timescales T ranging from 6 h to the longest fiber technology of time between a seizure pair (Fig.

We refer to this set of correlations as fiber technology temporal correlation pattern of seizure pathways. These fluctuations were signs of additional, timescale-dependent changes in seizure pathways.

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Comments:

18.03.2020 in 08:53 Terg:
It is exact

23.03.2020 in 17:39 Vikasa:
This variant does not approach me. Perhaps there are still variants?